The ins and outs of serine integrase site-specific recombination.
Current Opinion in Structural Biology（2014）
摘要
•A serine integrase–DNA complex structure provides the basis for site selectivity.•A coiled-coil motif influences synaptic efficiency and promotes attP×attB recombination.•A recombination directionality factor stimulates excision and inhibits integration.•The RDF may bind the coiled-coil motif, altering site-dependent synapsis efficiency.
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