Suitability of histopathology as an additional endpoint to the isolated chicken eye test for classification of non-extreme ph detergent and cleaning products

•Development and testing of histopathological criteria as additional endpoint to ICE.•Predictivity of histopathology to identify GHS Cat. 1 non-extreme pH detergent & cleaning products.•Mechanistic insights on non-extreme pH detergent and cleaning products ocular effects.•Identification of serious eye damage caused by persistent/irreversible tissue effects.•Comparison between in vitro versus additivity approach eye hazard classification.