3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitor.

Bioorganic & Medicinal Chemistry Letters（2014）

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摘要

Many adamantane derivatives have been demonstrated to function as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 3-Amino-N-adamantyl-3-methylbutanamide derivatives were optimized by structure-based drug design. Compound 8j exhibited a good in vitro and ex vivo inhibitory activity against both human and mouse 11β-HSD1.

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关键词

11β-Hydroxysteroid dehydrogenase type 1 inhibitor,3-Amino-N-adamantyl-3-methylbutanamide,Structure-based drug design,Anti-diabetes

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