Wound healing properties of a 3-D scaffold comprising soluble silkworm gland hydrolysate and human collagen.

•The regenerative ability of a 3-D microporous scaffold comprising soluble silkworm gland hydrolysate (SSGH) and human collagen in a tissue injury model.•The protein release and antioxidative properties of the SSGH/collagen to enhance proliferation, the attachment of skin fibroblasts and prevents apoptosis.•Cytocompatibility of the SSGH/collagen scaffold was demonstrated using mesenchymal stem cells from human umbilical cord.•The SSGH/collagen scaffold accelerated wound re-epithelialization over a 15-day period.