Plasmodium falciparum proteases hydrolyze plasminogen, generating angiostatin-like fragments.

Pollyana M S Melo,Piero Bagnaresi,Thaysa Paschoalin,Izaura Y Hirata,Marcos L Gazarini,Adriana K Carmona

Molecular and Biochemical Parasitology（2014）

引用 11|浏览16

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摘要

P. falciparum (P) proteases hydrolyze the multifunctional protein plasminogen (Plg) generating active fragments capable of inhibiting angiogenesis and eliciting calcium response in HUVEC.

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关键词

Malaria,Plasmodium,Plasminogen,Angiostatin,Plasmin

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