Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells.

•Acetylsalicylic acid (ASA) inhibits cyclooxygenase (COX) by irreversible acetylation.•The capsaicin receptor TRPV1 was suggested as a putative additional target of ASA.•ASA (1μM) enhanced tachyphylaxis of TRPV1 during repeated capsaicin stimulation.•Our data suggest inhibition of the cloned TRPV1 by low ASA doses independent of COX.