Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.
Biochemical and Biophysical Research Communications（2014）
摘要
•Conserved binding mechanism of p53TAD peptide among Bcl-2 family proteins.•Targeting of MDM2-inhibiting 12-1 peptide to anti-apoptotic Bcl-XL.•A structural model for the Bcl-XL/12-1 peptide complex.•The 12-1 and pro-apoptotic BH3 peptides share the binding site of Bcl-XL.•Dual-targeting mechanism of 12-1 peptide to MDM2 and Bcl-XL.
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关键词
p53 transactivation domain,MDM2-inhibiting peptide,Bcl-2 family proteins,NMR spectroscopy,Dual-targeting,Cancer therapy
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