Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells.

Karin I van Ede,Konrad P J Gaisch,Martin van den Berg,Majorie B M van Duursen

Toxicology Letters（2014）

引用 12|浏览1

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摘要

•Relative potencies (REPs) of dioxin-like compounds (DLCs) in lymphocytes (PBLs).•REPs for some DLCs varied by species (human vs. mouse) and congener.•REPs for PCB 126 in human PBLs significantly lower than WHO TEF.•In vitro-derived REPs similar to systemic REPs from in vivo experiments.•Human PBL-derived REPs contribute to improved human risk assessment for DLCs.

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关键词

AhR,BMR,CYP,DLC,EROD,HepG2,1234678-HpCDD,123678-HxCDD,1234678-HpCDF,1234789-HpCDF,123478-HxCDF,234678-HxCDF,NDL,PBL,PAH,PCB,PCB 74,PCB 77,PCB 105,PCB 118,PCB 126,PCB 153,PCB 156,PCB 167,PCB 169,PCB 189,PCDD,PCDF,12378-PeCDD,23478-PeCDF,REP,TCDD,2378-TCDF,TEF

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