Hypoxic preconditioning reinforces cellular functions of autologous peripheral blood-derived cells in rabbit hindlimb ischemia model.

Tomoaki Kudo,Tohru Hosoyama,Makoto Samura,Shunsaku Katsura,Arata Nishimoto,Naruji Kugimiya,Yasuhiko Fujii,Tao-Sheng Li,Kimikazu Hamano

Biochemical and Biophysical Research Communications（2014）

引用 19|浏览5

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摘要

•Hypoxic preconditioning reinforces cellular functions of rabbit and human PBMNCs.•Preconditioned autologous PBMNCs resulted in neovascularization in ischemic limb.•Blood flow in ischemic limb was improved by preconditioned autologous PBMNCs.•Hypoxic preconditioning of PBMNCs is novel therapeutic approach for ischemia.

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关键词

RT-PCR,CXCR4,GAPDH,ROS,DCF,DAPI,PBMNC

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