Human chitotriosidase CHIT1 cross reacts with mammalian-like substrates.

Tanja Larsen,Yayoi Yoshimura,Bjørn G R Voldborg,Giuseppe Cazzamali,Nicolai V Bovin,Ulrika Westerlind,Monica M Palcic,Jørgen J Leisner

FEBS Letters（2014）

引用 8|浏览10

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摘要

•Background: The human chitotriosidase contributes to defense against chitin-containing pathogens.•Results: Chitotriosidase hydrolyzes model substrates for glycolipids and glycoproteins motifs.•Conclusion: The GalNAcβ1-4GlcNAc (LacdiNAc) motif was a hitherto unrecognized substrate.•Significance: The chitotriosidase may target LacdiNAc motifs found in mammalian and invertebrate cells.

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关键词

CHIT1,AMCase

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