Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

    The Journal of experimental medicine, Volume 211, Issue 2, 2014, Pages 281-295.

    Cited by: 12|Bibtex|Views0|Links
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    Keywords:
    signal transduction

    Abstract:

    Cytochrome P450 (CYP) epoxygenases generate bioactive lipid epoxides which can be further metabolized to supposedly less active diols by the soluble epoxide hydrolase (sEH). As the role of epoxides and diols in angiogenesis is unclear, we compared retinal vasculature development in wild-type and sEH(-/-) mice. Deletion of the sEH signific...More

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