The ABCA1 domain responsible for interaction with HIV-1 Nef is conformational and not linear.

Daria Jacob,Ruth Hunegnaw,Tatyana A Sabyrzyanova,Tatiana Pushkarsky,Vladimir O Chekhov,Alexei A Adzhubei,Tatyana S Kalebina,Michael Bukrinsky

Biochemical and Biophysical Research Communications（2014）

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摘要

•HIV-1 protein Nef interacts with cellular cholesterol transporter ABCA1.•The C-terminal cytoplasmic tail of ABCA1 is necessary for ABCA1-Nef interaction.•The C-terminal cytoplasmic tail of ABCA1 does not bind Nef.•Molecular modeling predicts a conformational epitope responsible for Nef binding.

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关键词

ABCA1,HIV-1,Nef,HDL,HEK,Hcf1

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