Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons.

Souvik Karmakar,Weidong Zhang,Gul Ahmad,Workineh Torben,Mayeen U Alam,Loc Le,Raymond T Damian,Roman F Wolf,Gary L White,David W Carey,Darrick Carter,Steven G Reed,Afzal A Siddiqui

Vaccine（2014）

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摘要

•Sm-p80 vaccine originally developed for Schistosoma mansoni confers protection against Schistosoma haematobium.•Sm-p80 vaccine has a high likelihood of success against both intestinal and urinary schistosomiasis.•Schistosomiasis control should encompass mass drug/vaccine administration or MDVA: a vaccine implementation scheme that would entail treating infected individuals with praziquantel and then vaccinating them with a schistosome vaccine.

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关键词

Schistosome vaccine,Intestinal schistosomiasis,Urinary schistosomiasis,Schistosoma mansoni,Schistosoma haematobium,Sm-p80,Calpain,Nonhuman primate,Baboons

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