BCG Δzmp1 vaccine induces enhanced antigen specific immune responses in cattle.

Bhagwati Khatri,Adam Whelan,Derek Clifford,Agnese Petrera,Peter Sander,H Martin Vordermeier

Vaccine（2014）

引用 14|浏览15

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摘要

•BCG Danish Δzmp1 mutant strain targets phagosome maturation.•Immunogenicity testing of BCG Danish Δzmp1 and Pasteur Δzmp1::aph in cattle.•Cattle vaccinated with BCG Danish Δzmp1 and Pasteur Δzmp1::aph showed enhanced T cell memory responses and IFN-γ responses compared to BCG WT.•BCG Danish Δzmp1 selected for efficacy study in cattle against bovine tuberculosis.

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关键词

Tuberculosis,Bovine tuberculosis,BCG,Zinc metalloprotease 1 deletion,Cattle

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