Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
NATURE CHEMICAL BIOLOGY(2014)
摘要
llosteric small-molecule inhibitors of the p53-induced oncogenic phosphatase Wip1 bind at a ‘flap’ subdomain near the catalytic site. Inhibitor GSK2830371 inhibits the phosphatase and oncogenic activities in cell lines and a xenograft tumor model.
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关键词
nature chemical biology, science
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