Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells.

Jeong-Im Woo,Sung-Hee Kil,Huiqi Pan,Yoo Jin Lee,David J Lim,Sung K Moon

Biochemical and Biophysical Research Communications（2014）

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摘要

•DEFB4 is up-regulated by nontypeable H. influenzae through NF-κB activation.•The distal NF-κB motif of DEFB4 responds to nontypeable H. influenzae.•p65 NF-κB binds to the distal NF-κB motif of DEFB4 by nontypeable H. influenzae.•The distal NF-κB motif functions as an enhancer for DEFB4 regulation.

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关键词

Otitis media,Defensin,Middle ear,Innate immunity,Inflammation

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