Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies.

Yuki Kawakami,Shiori Hirano,Mai Kinoshita,Akemi Otsuki,Toshiko Suzuki-Yamamoto,Makiko Suzuki,Masumi Kimoto,Sae Sasabe,Mitsuo Fukushima,Koji Kishimoto,Takashi Izumi,Toru Oga,Shuh Narumiya,Mitsuaki Sugahara,Masashi Miyano,Shozo Yamamoto,Yoshitaka Takahashi

Biochimica et Biophysica Acta (BBA) - General Subjects（2014）

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摘要

•An effect of anti-leukotriene C4 monoclonal and single-chain antibodies was examined.•These antibodies inhibited binding of leukotrienes to their receptors.•The induction by leukotrienes of inflammatory cytokines was also suppressed.•The monoclonal antibody reduced eosinophil infiltration in a murine model of asthma.•The monoclonal antibody bound to cysteinyl leukotriene receptor antagonists.

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BAL,CHO,CysLT1R,CysLT2R,GAPDH,HE,IL-8,LT,mAbLTC,MCP-1,OVA,PAS,scFvLTC

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