Adipose tissue macrophages (ATM) of obese patients are releasing increased levels of prolactin during an inflammatory challenge: a role for prolactin in diabesity?

Thomas Bouckenooghe,Giorgia Sisino,Sandra Aurientis,Giulia Chinetti-Gbaguidi,Julie Kerr-Conte,Bart Staels,Pierre Fontaine,Laurent Storme,François Pattou,Anne Vambergue

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2014）

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摘要

•Hyperglycemia and inflammation are inducing prolactin expression by macrophages.•Prolactin expression by adipose tissue is increasing with obesity and diabetes.•Prolactinemia is increased in obese subjects.•Prolactin expression depends on Pit-1 transcription factor.•Pit-1 expression is parallel to prolactin expression.

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关键词

Diabetes,Obesity,Macrophages,Prolactin,Hyperglycemia,Inflammation

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