The synthesis and structure revision of NSC-134754.

Jennie A Hickin,Afshan Ahmed,Katharina Fucke,Margaret Ashcroft,Keith Jones

CHEMICAL COMMUNICATIONS（2014）

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摘要

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.

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关键词

crystallography,molecular,biological assay

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