Endothelial function and carotid intima-media thickness in giant-cell arteritis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION(2014)
摘要
BackgroundVascular endothelial dysfunction and intima-media thickness are characteristic aspects of several vasculitides. We investigated retrospectively the impact of steroid treatment on endothelial dysfunction and intima-media thickness in giant-cell arteritis. MethodsForty-one patients with giant-cell arteritis (28 female and 13 male) underwent flow-mediated dilatation, a marker of endothelial function, and carotid intima-media thickness within 24h after diagnosis and 6months thereafter. Both parameters were investigated in 41 patients of an age- and gender-matched control group. ResultsBrachial flow-mediated dilatation response at baseline was 34 % (02 , 80 ) and 17 % (02 , 48 ) in giant-cell arteritis patients and control group, respectively. After 6months treatment, flow-mediated dilatation response was 28 % (04 , 48 ) in patients with giant-cell arteritis (P=0066 ) and 14 % (01 , 55 ) in the control group (P=0741 ). In contrast, mean carotid intima-media thickness of giant-cell arteritis patients improved significantly between baseline [10 mm (079 , 12 )] and 6-month follow-up [082 mm (07 , 104 ), P<0001 ]. Subjects with additional symptoms of polymyalgia rheumatica had a notable enlargement of carotid intima-media thickness [123 mm (114 , 209 )] compared to giant-cell arteritis patients without polymyalgia rheumatica at baseline [091 mm (076 , 104 ), P=0001 ] and 6-month follow-up [116 mm (080 , 126 ) vs. 077 mm (068 , 088 ), P=0009 ]. ConclusionSteroid therapy has no influence on endothelial function but does significantly improve carotid intima-media thickness in giant-cell arteritis. This divergence of endothelial function and intima-media thickness reflects the specifity of giant-cell arteritis for cerebrovascular arteries thereby sparing the brachial arteries.
更多查看译文
关键词
Arteriosclerosis,Giant-cell arteritis,polymyalgia rheumatica,sonography,vasculitis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要