The effects of miR-467b on lipoprotein lipase (LPL) expression, pro-inflammatory cytokine, lipid levels and atherosclerotic lesions in apolipoprotein E knockout mice.

•We observe that miR-467b protects apoE−/− mice from atherosclerosis.•miR-467b reducing lipid accumulation and inflammatory by targeting LPL in vivo.•miR-467b inhibits LPL in aorta and macrophages of apoE−/− mice.•The paper explains the regulation mechanism of LPL in vivo.