Seleno- and telluro-xylofuranosides attenuate Mn-induced toxicity in C. elegans via the DAF-16/FOXO pathway.

Suzi G N Wollenhaupt,Ana Thalita Soares,Willian G Salgueiro,Simone Noremberg,Gabriel Reis,Carine Viana,Priscila Gubert,Felix A Soares,Ricardo F Affeldt,Diogo S Lüdtke,Francielli W Santos,Cristiane C Denardin,Michael Aschner,Daiana S Avila

Food and Chemical Toxicology（2014）

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摘要

•Se- and Te-xylofuranosides depicted low toxicity in C. elegans.•The compounds protected from toxicity-induced by Mn.•Se- and Te-xylofuranosides increased the expression SOD-3.•Compounds induced nuclear translocation of DAF-16/FOXO.•DAF-16 cascade modulation is a possible mechanism of organohalcogens.

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关键词

Xylofuranoside,C. elegans,Oxidative stress,DAF-16,SOD,Manganese

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