Alpha-lipoic acid protects oxidative stress, changes in cholinergic system and tissue histopathology during co-exposure to arsenic-dichlorvos in rats.

Nidhi Dwivedi,Govinder Flora,Pramod Kushwaha,Swaran J S Flora

Environmental Toxicology and Pharmacology（2014）

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摘要

•Present study reveals that arsenic-DDVP co-exposure leads to oxidative stress.•Co-exposure also induced cell death, neurological and pathological changes.•Co-exposure to As to DDVP leads to few synergistic or antagonistic effects.•α-Lipoic acid partially protected arsenic-DDVP induced toxic effects.

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关键词

Arsenic,DDVP,α-Lipoic acid,Oxidative stress,Brain biogenic amines,Histopathology

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