Systematic development of an UPLC-MS/MS method for the determination of tricyclic antidepressants in human urine.

Erin E Chambers,Matthew J Woodcock,Jessalynn P Wheaton,Teresa M Pekol,Diane M Diehl

Journal of Pharmaceutical and Biomedical Analysis（2014）

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摘要

•The UPLC–MS/MS method measures five tricyclic antidepressants in human urine.•Simple screening protocols and subsequent optimization delivered the final method.•The method was evaluated against current FDA guidelines.•The work includes an assessment of incurred sample reanalysis (ISR).

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关键词

Tricyclic,Antidepressant,UPLC–MS/MS,Urine,Incurred Sample Reanalysis

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