Paradigm shift in NMDA receptor drug development.
EXPERT OPINION ON THERAPEUTIC TARGETS(2005)
摘要
Low-affinity, uncompetitive antagonists with rapid 'off-rates', such as memantine offer protection from dementia and other neurological disorders, but break all the old rules of screening for new drugs by high-affinity binding.
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关键词
antagonist,memantine,NMDA receptor
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