Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration.

Daniela K Montes,Marianne Brenet,Vanessa C Muñoz,Patricia V Burgos,Carolina I Villanueva,Carlos D Figueroa,Carlos B González

Biochemical and Biophysical Research Communications（2013）

引用 10|浏览3

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摘要

•AVP induces mTOR phosphorylation in A-10 cells cultured in high glucose concentration.•The mTOR phosphorylation is mediated by the PI3K/Akt pathway activation.•The AVP-induced mTOR phosphorylation inhibited autophagy and stimulated cell proliferation.

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关键词

AVP,mTOR,mTORC1,PI3K,AMPK,PKC,TSC1/TSC2,Rheb,PLD,ERK

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