Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation

    Antioxidants & redox signaling, Volume 20, Issue 17, 2014, Pages 2667-2680.

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    Keywords:
    nitric oxidearachidonate 5 lipoxygenasesignal transduction

    Abstract:

    The reaction of nitric oxide and nitrite-derived species with polyunsaturated fatty acids yields electrophilic fatty acid nitroalkene derivatives (NO2-FA), which display anti-inflammatory properties. Given that the 5-lipoxygenase (5-LO, ALOX5) possesses critical nucleophilic amino acids, which are potentially sensitive to electrophilic mo...More

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