Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert,Carla A Ibrahim-Verbaas,Denise Harold,Adam C Naj,Rebecca Sims,Céline Bellenguez,Gyungah Jun,Anita L DeStefano,Joshua C Bis,Gary W Beecham,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A Thornton-Wells,Nicola Jones,Albert V Smith,Vincent Chouraki,Charlene Thomas,M Arfan Ikram,Diana Zelenika,Badri N Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Amy Gerrish,Helena Schmidt,Brian Kunkle,Melanie L Dunstan,Agustin Ruiz,Marie-Thérèse Bihoreau,Seung-Hoan Choi,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Alfredo Ramirez,Olivier Hanon,Annette L Fitzpatrick,Joseph D Buxbaum,Dominique Campion,Paul K Crane,Clinton Baldwin,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga, David Craig,Najaf Amin,Claudine Berr,Oscar L Lopez,Philip L De Jager,Vincent Deramecourt,Janet A Johnston,Denis Evans,Simon Lovestone,Luc Letenneur,Francisco J Morón,David C Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison M Goate,Nathalie Fiévet,Matthew J Huentelman,Michael Gill,Kristelle Brown,M Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B Larson,Robert Green,Amanda J Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Jordi Clarimon,Alberto Lleo,Anthony Bayer,Debby W Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petroula Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez-Garcia,Nick C Fox,John Hardy,Maria Candida Deniz Naranjo,Paolo Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Michelangelo Mancuso,Fiona Matthews,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,Maria Bullido,Francesco Panza,Paolo Caffarra,Benedetta Nacmias,John R Gilbert,Manuel Mayhaus,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alvarez,Fanggeng Zou,Otto Valladares,Steven G Younkin,Eliecer Coto,Kara L Hamilton-Nelson,Wei Gu,Cristina Razquin,Pau Pastor,Ignacio Mateo,Michael J Owen,Kelley M Faber,Palmi V Jonsson,Onofre Combarros,Michael C O'Donovan,Laura B Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H Mosley Jr,David A Bennett,Tamara B Harris,Laura Fratiglioni,Clive Holmes,Renee F A G de Bruijn,Peter Passmore,Thomas J Montine,Karolien Bettens,Jerome I Rotter,Alexis Brice,Kevin Morgan,Tatiana M Foroud,Walter A Kukull,Didier Hannequin,John F Powell, Michael A Nalls,Karen Ritchie,Kathryn L Lunetta,John S K Kauwe,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R Martin,Reinhold Schmidt,Dan Rujescu,Li-San Wang,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M Nöthen,Caroline Graff,Bruce M Psaty,Lesley Jones,Jonathan L Haines,Peter A Holmans,Mark Lathrop,Margaret A Pericak-Vance,Lenore J Launer,Lindsay A Farrer,Cornelia M van Duijn,Christine Van Broeckhoven,Valentina Moskvina,Sudha Seshadri,Julie Williams,Gerard D Schellenberg,Philippe Amouyel

NATURE GENETICS（2013）

引用 4337|浏览110

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摘要

Philippe Amouyel, Julie Williams, Gerard Schellenberg, Sudha Seshadri and colleagues report a meta-analysis of genome-wide association studies for late-onset Alzheimer's disease in 17,008 cases and 37,154 controls with replication in an additional 8,572 cases and 11,312 controls. They identify 11 loci newly associated with Alzheimer's disease.

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关键词

Genome-wide association studies,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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