Development of azo-based fluorescent probes to detect different levels of hypoxia.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2013)
摘要
Let it shine: New hypoxia-sensitive fluorescent probes were developed; they consist of a rhodamine moiety with an azo group directly conjugated to the fluorophore. Because of an ultrafast conformational change around the NN bond, the compounds are nonfluorescent under normoxia. However, under hypoxia, the azo group is reduced, and a strongly fluorescent rhodamine derivative is released.
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关键词
azo compounds,bioorganic chemistry,fluorescent probes,imaging agents,oxygen concentration
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