Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA.

Hirokazu Mizoguchi,Takashi Kon-No,Hiroyuki Watanabe,Chizuko Watanabe,Akihiko Yonezawa,Takumi Sato,Tsukasa Sakurada,Shinobu Sakurada

Peptides（2013）

引用 4|浏览3

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摘要

•TAPA is μ-opioid receptor agonist does not have the affinity for κ-opioid receptors.•Spinal antinociception of TAPA is selectively mediated by spinal μ1-opioid receptors.•Spinal antinociception of TAPA is also mediated by spinal κ-opioid receptors.•Spinal antinociception of TAPA is mediated through the spinal release of α-neo-endorphin.•The multiple μ1-opioid receptors are involved in the spinal antinociception of TAPA.

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关键词

TAPA,Antinociception,μ-Opioid receptor,α-Neo-endorphin,Release,Spinal cord

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