A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min.

Patrizia Voehringer,René Fuertig,Boris Ferger

Journal of Chromatography B（2013）

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摘要

•Establishment of a fast and reliable LC–MS/MS method for the analysis of glycine.•No sample pre-treatment required.•Short analysis time of 5min.•Limit of quantitation of 100nM.•Useful for the analysis of brain microdialysis and CSF samples.

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aCSF,ANOVA,CE,CE–MS,CNS,CSF,CXP,DNFB,DP,ESI,FD,GABA,GC–MS,GlyT,GRI,HILIC,HPLC,LC–MS,LC–MS/MS,LOD,LOQ,MCE,MRM,NMDA,OPA,UV

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