Thin-film theories for two-phase reactive flow models of active cell motion.

J M Oliver,J R King, K J McKinlay,P D Brown,D M Grant,C A Scotchford,J V Wood

Mathematical Medicine and Biology: A Journal of the IMA（2005）

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摘要

The aim of this paper is to develop a broadly-applicable and self-consistent thin-film biphasic modelling framework for the full crawling cycle of a single animal cell. A hierarchy of thin-film two-phase ‘reactive flow’ models is derived; between them these cover a wide range of biologically relevant parameter regimes. The mathematical properties and biological implications of the resulting system...

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关键词

active cell motion,cell-crawling cycle,two-phase reactive flow model,poroviscous free surface flows,actin network dynamics,thin-film lubrication theory,osteoblast

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