Dosimetric predictors of biochemical control of prostate cancer in patients randomised to external beam radiotherapy with a boost of high dose rate brachytherapy.

Background: To correlate dose and volume dosimetric parameters (D-90 and V-100) with biochemical control in advanced prostate cancer treated with high-dose rate brachytherapy (HDR-BT). Methods: One hundred and eight patients received external beam radiotherapy (EBRT) to 35.75 Gy in 13 fractions followed by HDR-BT of 2 x 8.5 Gy. Kaplan-Meier freedom-from-biochemical relapse (FFbR; nadir + 2 mu g/L) fits were grouped by the first (Q1), second (Q2) and third (Q3) D-90 and V-100 quartiles. Groups were compared with the log-rank test. Univariate and multivariate Hazard Ratios (HR) for D-90 and V-100 and other co-variates (PSA, androgen deprivation therapy (ADT) were obtained using Cox's proportional hazard model. Results: FFbR was significantly higher in patients whose D-90 and V-100 were at or above the second and third quartile (log rank p <= 0.04). In multivariate analysis D-90, V-100 were significant covariates for risk of relapse. Conclusions: Dichotomising the data using 6 levels of response (above and below Q1, Q2 and Q3) showed a progressive and continuous improvement in biochemical control of disease across the entire dose (and volume) range. The data show that a minimum D-90 of 108% of the Prescribed dose should be the target to achieve. (C) 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 110 (2014) 110-113