A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.

Megumi Akamatsu,Hiroshi Takuma,Takenari Yamashita,Takuya Okada,Kazuko Keino-Masu,Kazuhiro Ishii,Shin Kwak,Masayuki Masu,Akira Tamaoka

Neuroscience Research（2013）

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摘要

•We established new in vivo mouse model expressing ALS-associated proteins.•In utero electroporation was used for this model.•TDP-43 inclusions were observed in the motor area of the cortex in the mouse brains.•These inclusions were phosphorylated and ubiquitinated as human pathology of ALS.•This method can be used for other proteins in the neurodegenerative diseases.

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关键词

Amyotrophic lateral sclerosis,TDP-43,In utero electroporation,Inclusion body

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