Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways.

Feng Zhang,Zili Zhang,Desong Kong,Xiaoping Zhang,Li Chen,Xiaojing Zhu,Yin Lu,Shizhong Zheng

Molecular and Cellular Endocrinology（2014）

引用 47|浏览22

暂无评分

摘要

•TMP inhibits Glu/Ins-induced HSC activation.•TMP inhibits InsR-mediated PI3K/AKT and ERK cascades in Glu/Ins-activated HSC.•TMP modulates the genes controlling ECM homeostasis in Glu/Ins-activated HSC.•TMP could be a promising antifibrotic candidate.

查看译文

关键词

α-SMA,BSA,CTGF,DMEM,ECM,ERK,FBS,GAPDH,Glu/Ins,HSC,InsR,JNK,MAPK,MMP,MTS,NAFLD,NASH,PBS,PI3K,T2DM,TIMP,TMP

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要