Allosteric lariat peptide inhibitors of Abl kinase.

V M Bharathikumar,Kris Barreto,John F Decoteau,C Ronald Geyer

CHEMBIOCHEM（2013）

引用 9|浏览2

暂无评分

摘要

Going against tradition: although most kinase inhibitors are ATP competitive, lariat peptides inhibit Abl kinase activity in an ATP-uncompetitive manner. Further, lariat peptides discriminated Src family kinases, and recognize the allosteric region that lies adjacent to the ATP binding pocket in the Abl kinase catalytic cleft.

查看译文

关键词

Abl kinase,combinatorial chemistry,enzyme inhibitors,lariat peptides,uncompetitive inhibition

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要