ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.

Tohru Yamamori,Shunsuke Meike,Masaki Nagane,Hironobu Yasui,Osamu Inanami

FEBS Letters（2013）

引用 98|浏览1

暂无评分

摘要

•Tunicamycin selectively suppresses Rad51 protein levels.•Tunicamycin stimulates Rad51 degradation via the 26S proteasome.•Tunicamycin impairs DSB repair and enhances radiosensitivity.•Glucose deprivation down-regulates Rad51 expression and DSB repair.

查看译文

关键词

DSB,ER,ERAD,IR,HR,NHEJ,RT-PCR,UPR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要