Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells.

Ana Manuel Dantas Machado,Claus Desler,Sisse Bøggild,Jesper A B Strickertsson,Lennart Friis-Hansen,Ceu Figueiredo,Raquel Seruca,Lene Juel Rasmussen

Mechanisms of Ageing and Development（2013）

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摘要

•Helicobacter pylori infection causes mtDNA mutations and a decrease of mtDNA content.•Decreased mtDNA fidelity correlates with decreased electron chain activity.•H. pylori infection targets mtDNA, in part, by inhibiting mtDNA repair activity.

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关键词

H. pylori,Mitochondria,Gastric cancer,DNA repair,Genetic instability

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