HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Carrie A. Adelman, Rafal L. Lolo,Nicolai J. Birkbak,Olga Murina,Kenichiro Matsuzaki,Zuzana Horejsi,Kalindi Parmar,Valérie Borel,J. Mark Skehel,Gordon Stamp,Alan D’Andrea,Alessandro A. Sartori,Charles Swanton,Simon J. Boulton

NATURE（2013）

引用 141|浏览11

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摘要

Interstrand crosslink (ICL) repair involves proteins whose mutation results in the disorder Fanconi anaemia: here gene knockdown studies in mice show that the absence of HELQ, a protein previously implicated in ICL repair, compromises germ cell development and results in tumour predisposition due to defective recombination at damaged replication forks.

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关键词

DNA recombination, Ovarian cancer, DNA damage and repair, Germline development

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