Evaluation of 13-valent pneumococcal conjugate vaccine and concomitant meningococcal group C conjugate vaccine in healthy infants and toddlers in Spain.

Javier Diez-Domingo,Alejandra Gurtman,Enrique Bernaola,Francisco Gimenez-Sanchez,Federico Martinon-Torres,Valentin Pineda-Solas,Alfonso Delgado,Pilar Infante-Marquez,John Z Liang,Peter C Giardina,William C Gruber,Emilio A Emini,Daniel A Scott

Vaccine（2013）

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摘要

•Study of 13-valent pneumococcal conjugate vaccine (PCV13) versus 7-valent PCV (PCV7).•Immune responses to PCVs and meningococcal C conjugate vaccine (MnCCV) assessed.•Immune responses to MnCCV were similar when coadministered with PCV7 or PCV13.•PCV13 elicited substantial antipneumococcal responses against all 13 serotypes.•Safety and tolerability were similar between the PCV7 and PCV13 groups.

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关键词

AE,CI,CRM197,e-diary,ELISA,GMC,GMT,Hib,IgG,IPD,MMR,MnC,MnCCV-CRM197,PCV7,PCV13,SAE,SBA,TCID50

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