[Relation between vascular endothelial growth factor expression and clinical pathological character in laryngeal squamous cell carcinoma].

OBJECTIVE:To approach the relation between vascular endothelial growth factor (VEGF) expression and clinical pathological character in laryngeal squamous cell carcinoma. METHOD:Immunohistochemical staining (SP) was used to evaluated the expression of VEGF and microvessel count (MVC) in tumor tissues from 87 patients with laryngeal squamous cell carcinoma. RESULT:VEGF immune response was mainly localized to the tumor cell cytoplasm, positive rate was 77%. In laryngeal squamous cell carcinoma, the wider the tumor invaded, the stronger VEGF expressed, the fewer the tumor invaded, the weaker VEGF expressed (P < 0.05); The lower the tumor differentiated, the stronger VEGF expressed, the higher the tumor differentiated, the weaker VEGF expressed (P < 0.05); The stronger VEGF expressed, the more MVC were (P < 0.01); The mean MVC in tumor tissues was obviously higher than that in surgical margin tissues (P < 0.01). CONCLUSION:In laryngeal squamous cell carcinoma, the expression of VEGF was markedly correlated with tumor stage and differentiation, was positively correlated with MVC. As a result, VEGF may have an important role in the progression of laryngeal squamous the carcinoma.