Female premenopausal fracture risk is associated with gc phenotype.

JOURNAL OF BONE AND MINERAL RESEARCH(2004)

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摘要
The phenotype of the vitamin D binding and macrophage activating protein, Gc, is a predictor of premenopausal bone fracture risk, possibly mediated through activation of osteoclasts. This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years).
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关键词
bone fractures,bone densitometry,polymorphisms,single nucleotide polymorphism,group-specific component,vitamin D binding protein,Gc-MAF,soluble CD163
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