Angiotensin AT1 receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodiliation in normotensive diabetic rats

N. Horio,A. C. Clermont, A. Abiko, T. Abiko, B. D. Shoelson,S.-E. Bursell,E. P. Feener

Diabetologia（2004）

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摘要

The renin angiotensin system is emerging as a potential therapeutic target for diabetic retinopathy. This study examines the effects of angiotensin-converting-enzyme inhibition by captopril and angiotensin AT1 receptor antagonism using candesartan-cilexetil on retinal blood flow and acetylcholine-stimulated vasodilatation in normotensive diabetic rats.

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关键词

Acetylcholine,angiography,angiotensin-converting enzyme,angiotensin type 1 receptor,blood flow,diabetes,diacylglycerol,rats,retina,vasodilatation

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