Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

Brenna Osborne,Gregory J Cooney,Nigel Turner

Biochimica et Biophysica Acta (BBA) - General Subjects（2014）

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摘要

•The scope and role of lysine acylation in mitochondria is reviewed.•Sirtuin enzymes are located in mitochondria and regulate metabolic enzymes.•SIRT3 deacetylates many proteins, but its role in metabolism requires more study.•SIRT4 and SIRT5 have few validated targets and are an exciting area of new research.

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关键词

AceCS2,ADP,CPS1,CPT1,CR,FOXO3a,GDH,HeLa,HIF-1α,HMGCS2,IDH2,LCAD,MCAD,MCD,MDH,MEFs,mPTP,MRPL10,NAD+,NADPH,NDUFA9,OTC,PDH,PDH E1α,PGC1α,PTM,ROS,SDHa,SOD2,TCA

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