Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway

Chemico-Biological Interactions（2013）

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摘要

•Brazilein caused cell cycle arrest at the G1 phase in MCF-7 cells.•GSK-3β/β-catenin/cyclin D1 pathway was involved in its action mechanism.•It is promising to develop brazilein as a lead compound to treat cancer.

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关键词

Brazilein,Cell cycle,GSK-3β/β-Catenin pathway,Cyclin D1,Breast cancer

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