The RNA-binding protein repertoire of embryonic stem cells

S Chul Kwon,Hyerim Yi,Katrin Eichelbaum,Sophia Föhr,Bernd Fischer,Kwon Tae You,Alfredo Castello,Jeroen Krijgsveld,Matthias W Hentze,V Narry Kim

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2013）

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摘要

mRNA-interactome capture approach in embryonic stem cells (ESCs) has led to the identification of 283 novel RNA-binding protein (RBP) candidates, of which 68 are preferentially expressed in ESCs. Validation of two known E3 ubiquitin ligases as RBPs reveals an intriguing potential link between RNA biology and protein-modification pathways.

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nature structural and molecular biology, science

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