Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation.

Mingyao Wang,Guang Cheng,Samir S Khariwala,Dipankar Bandyopadhyay,Peter W Villalta,Silvia Balbo,Stephen S Hecht

Chemico-Biological Interactions（2013）

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摘要

•The DNA adduct 7-(2′-carboxyethyl)guanine is present in human liver.•Nitrosation of dihydrouracil in vivo leads to elevated 7-CEGua in rat hepatic DNA.•The hepatocarcinogen N-nitrosodihydrouracil can be formed in vivo in rats.•The normal human pyrimidine metabolite dihydrouracil may be a carcinogen precursor.•Mass spectrometry detects 7-carboxyethylguanine in human leukocyte DNA.

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关键词

7-(2′-carboxyethyl)guanine,Dihydrouracil,β-Ureidopropionic acid,Acrylic acid,Endogenous nitrosation,N-Nitrosodihydrouracil

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