IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway.

Bing Gong,Yong Pan,Wei Zhao,Lindsay Knable,Prashant Vempati,Shimul Begum,Lap Ho,Jun Wang,Shrishailam Yemul,Scott Barnum,Amanda Bilski,Ben Y Gong,Giulio M Pasinetti

Molecular Immunology（2013）

引用 36|浏览4

暂无评分

摘要

•C5aR expression in the brain is crucial for normal cognitive function and synaptic plasticity.•C5aR deficits down-regulate the CaMKII-Erk1-pCREB signaling pathway.•C5a promotes the pCREB/CEBP pathway through an activation of GluR1/2 receptors.•hrC5a improves synaptic function in AD mouse models.•IVIG improves synaptic function through a regulation of C5a levels in Tg2576 mice.

查看译文

关键词

Alzheimer's disease,Complement component C5a,IVIG,pCREB,LTP,Cognitive function

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要