Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes.

Alessio Porta,Maurizio Pasi,Enrico Brunoldi,Giuseppe Zanoni,Giovanni Vidari

Chemistry and Physics of Lipids（2013）

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摘要

•Validation of a general synthetic strategy to A4-NeuroPs.•Synthesis of 17-A4-NeuroP.•17-A4-NeuroP adduct with GSH thiol group.•Stereoselective semi-hydrogenation of a skipped diyne to the corresponding1,4-diene.•Diastereoselective aspects of the Julia-Kocienski reaction.

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关键词

A4-Neuroprostanes,Docosahexaenoic acid (DHA),Oxidative stress,Total synthesis,17-A4-NeuroP

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