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    • Minimal Sequence Variability of the Region of HIV-1 Integrase Targeted by the Abbott RealTime HIV-1 Viral Load Assay in Clinical Specimens with Reduced Susceptibility to Raltegravir

    Thomas P. Young,Laura A. Napolitano,Agnes C. Paquet,Neil T. Parkin,Signe Fransen,Roger Trinh,Mojgan Haddad,John Hackett,Gavin A. Cloherty

    Journal of Virological Methods（2013）

    Abbott Mol Inc

    Cited 2|Views14
    Abstract
    The Abbott RealTime (ART) HIV-1 assay targets the integrase region and is designed to tolerate mismatches. Variability in integrase sequences comprising the assay target regions from >1000 clinical specimens submitted for phenotypic and genotypic raltegravir resistance testing were analyzed. In this large collection of sequences from clinical specimens, the number and location of raltegravir resistance associated mutations did not differ from those tested previously and shown not to result in under-estimation of viral loads.
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    Key words
    HIV,Assay,Integrase inhibitor resistance,Sequence variability
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